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PUBLICATIONS
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2023
Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation
Banerjee S, Varga JK, Kumar M, Zoltsman G, Rotem-Bamberger S, Cohen-Kfir E, Isupov MN, Rosenzweig R, Schueler-Furman O, Wiener R. EMBO Rep. 2023 Dec 6;24(12):e56920. doi: 10.15252/embr.202356920. Epub 2023 Nov 21. PMID: 37988244
Regulation of major bacterial survival strategies by transcripts sequestration in a membraneless organelle
Szoke T, Goldberger O, Albocher-Kedem N, Barsheshet M, Dezorella N, Nussbaum-Shochat A, Wiener R, Schuldiner M, Amster-Choder O. Cell Rep. 2023 Nov 28;42(11):113393. doi: 10.1016/j.celrep.2023.113393. Epub 2023 Nov 6. PMID: 37934665
Antibody response in elderly vaccinated four times with an mRNA anti-COVID-19 vaccine
Rouvinski A, Friedman A, Kirillov S, Attal JH, Kumari S, Fahoum J, Wiener R, Magen S, Plotkin Y, Chemtob D, Bercovier H.Sci Rep. 2023 Aug 29;13(1):14165. doi: 10.1038/s41598-023-41399-5. PMID: 37644113
Intramuscular mRNA BNT162b2 vaccine against SARS-CoV-2 induces neutralizing salivary IgA
Stolovich-Rain M, Kumari S, Friedman A, Kirillov S, Socol Y, Billan M, Pal RR, Das K, Golding P, Oiknine-Djian E, Sirhan S, Sagie MB, Cohen-Kfir E, Gold N, Fahoum J, Kumar M, Elgrably-Weiss M, Zhou B, Ravins M, Gatt YE, Bhattacharya S, Zelig O, Wiener R, Wolf DG, Elinav H, Strahilevitz J, Padawer D, Baraz L, Rouvinski A.Front Immunol. 2023 Jan 30;13:933347. doi: 10.3389/fimmu.2022.933347. eCollection 2022. PMID: 36798518
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2022
Ubiquitination Occurs in the Mitochondrial Matrix by Eclipsed Targeted Components of the Ubiquitination Machinery Zhang Y, Karmon O, Das K, Wiener R, Lehming N, Pines O.Cells. 2022 Dec 17;11(24):4109. doi: 10.3390/cells11244109. PMID: 36552873
S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair . Amar-Schwartz A, Ben Hur V, Jbara A, Cohen Y, Barnabas GD, Arbib E, Siegfried Z, Mashahreh B, Hassouna F, Shilo A, Abu-Odeh M, Berger M, Wiener R, Aqeilan R, Geiger T, Karni R.Elife. 2022 Oct 3;11:e79128. doi: 10.7554/eLife.79128. PMID: 36189922
Overexpression of UBA5 in Cells Mimics the Phenotype of Cells Lacking UBA5
Kumari S, Banerjee S, Kumar M, Hayashi A, Solaimuthu B, Cohen-Kfir E, Shaul YD, Rouvinski A, Wiener R, nt J Mol Sci. 2022 Jul 4;23(13):7445. doi: 10.3390/ijms23137445. PMID: 35806453
Structural basis for long-chain isoprenoid synthesis by cis-prenyltransferases. Giladi M, Lisnyansky Bar-El M, Vaňková P, Ferofontov A, Melvin E, Alkaderi S, Kavan D, Redko B, Haimov E, Wiener R, Man P, Haitin Y.Sci Adv. 2022 May 20;8(20):eabn1171. doi: 10.1126/sciadv.abn1171. Epub 2022 May 18. PMID: 35584224
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2021
Structural basis for UFM1 transfer from UBA5 to UFC1
Manoj Kumar, Prasanth Padala, Jamal Fahoum, Fouad Hassouna, Tomer Tsaban, Guy Zoltsman, Sayanika Banerjee, Einav Cohen-Kfir, Moshe Dessau, Rina Rosenzweig, Michail N. Isupov, Ora Schueler-Furman & Reuven Wiener, Nature Communications. 2021, 12, 5708. https://doi.org/10.1038/s41467-021-25994-6
CEACAM1 Activation by CbpF-Expressing E. coli
Amjad Shhadeh, Johanna Galaski, Tamar Alon-Maimon , Jamal Fahoum , Reuven Wiener , Daniel J Slade , Ofer Mandelboim , Gilad Bachrach, Front Cell Infect Microbiol. 2021 Jul 29;11:699015. PMID:34395310
CladeOScope: functional interactions through the prism of clade-wise co-evolution
Tomer Tsaban, Doron Stupp , Dana Sherill-Rofe , Idit Bloch , Elad Sharon , Ora Schueler-Furman , Reuven Wiener , Yuval Tabach, NAR Genom Bioinform. 2021 Apr 20;3(2):lqab024. PMID 33928243
RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment
Pallabi Basu , Maya Elgrably-Weiss , Fouad Hassouna , Manoj Kumar , Reuven Wiener , Shoshy Altuvia,
Nat Commun. 2021 Apr 21;12(1):2249. doi: 10.1038/s41467-021-22553-x. PMID 33883550
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2020
Decrypting UFMylation: How Proteins Are Modified with UFM1.
Banerjee S, Kumar M, Wiener R, Biomolecules. 2020 Oct 14;10(10):1442. Review. PMID: 33066455
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2019
A direct interaction between survivin and myosin II is required for cytokinesis.
Babkoff A, Cohen-Kfir E, Aharon H, Ronen D, Rosenberg M, Wiener R, Ravid S, J Cell Sci. 2019 Jul 17;132(14) PMID: 31315909
Closing the gap of ubiquitin activation.
Kumar M, Wiener R, Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15319-15321. PMID: 31278148
Assays for dissecting the in vitro enzymatic activity of yeast Ubc7.
Mashahreh B, Reiss Y, Wiener R, Ravid T, Methods Enzymol. 2019;619:71-95. PMID: 30910030
An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation.
Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev AA, Isupov MN, Cohen-Kfir E, Wiener R, J Mol Biol. 2019 Feb 1;431(3):463-478. PMID: 30412706
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2018
Trans-binding of UFM1 to UBA5 stimulates UBA5 homodimerization and ATP binding.
Mashahreh B, Hassouna F, Soudah N, Cohen-Kfir E, Strulovich R, Haitin Y, Wiener R, FASEB J. 2018 May;32(5):2794-2802. PMID: 29295865
A Sub-population of Group A Streptococcus Elicits a Population-wide Production of Bacteriocins to Establish Dominance in the Host.
Hertzog BB, Kaufman Y, Biswas D, Ravins M, Ambalavanan P, Wiener R, Angeli V, Chen SL, Hanski E, Cell Host Microbe. 2018 Mar 14;23(3):312-323.e6. PMID: 29544095
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2017
The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages.
Padala P, Soudah N, Giladi M, Haitin Y, Isupov MN, Wiener R, J Mol Biol. 2017 Dec 8;429(24):3801-3813. PMID: 29111344
Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence.
Padala P, Oweis W, Mashahreh B, Soudah N, Cohen-Kfir E, Todd EA, Berndsen CE, Wiener R, Sci Rep. 2017 Mar 30;7(1):508. PMID: 28360427
Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases.
Attali I, Tobelaim WS, Persaud A, Motamedchaboki K, Simpson-Lavy KJ, Mashahreh B, Levin-Kravets O, Keren-Kaplan T, Pilzer I, Kupiec M, Wiener R, Wolf DA, Rotin D, Prag G, EMBO J. 2017 Feb 15;36(4):425-440. PMID: 28069708
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2016
Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex.
Oweis W, Padala P, Hassouna F, Cohen-Kfir E, Gibbs DR, Todd EA, Berndsen CE, Wiener R, Cell Rep. 2016 Sep 20;16(12):3113-3120. PMID: 27653677
The Vps27/Hrs/STAM (VHS) Domain of the Signal-transducing Adaptor Molecule (STAM) Directs Associated Molecule with the SH3 Domain of STAM (AMSH) Specificity to Longer Ubiquitin Chains and Dictates the Position of Cleavage.
Baiady N, Padala P, Mashahreh B, Cohen-Kfir E, Todd EA, Du Pont KE, Berndsen CE, Wiener R, J Biol Chem. 2016 Jan 22;291(4):2033-42. PMID: 26601948
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2015
Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases.
Cohen I, Wiener R, Reiss Y, Ravid T, Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E625-32. PMID: 25646477
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2013
Ubiquitin: molecular modeling and simulations.
Ganoth A, Tsfadia Y, Wiener R, J Mol Graph Model. 2013 Nov;46:29-40.
PMID: 24113788
E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1.
Wiener R, DiBello AT, Lombardi PM, Guzzo CM, Zhang X, Matunis MJ, Wolberger C, Nat Struct Mol Biol. 2013 Sep;20(9):1033-9. PMID: 23955022
A new DUB makes linear ubiquitin a party to its own destruction.
Wiener R, Wolberger C, Cell. 2013 Jun 6;153(6):1189-91. PMID: 23746836
A conserved asparagine has a structural role in ubiquitin-conjugating enzymes.
Berndsen CE, Wiener R, Yu IW, Ringel AE, Wolberger C, Nat Chem Biol. 2013 Mar;9(3):154-6. PMID: 23292652
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